p53 & Cyclin D1 expression in surgically resected clear margins of oral squamous cell carcinoma

p53 & Cyclin D1 expression in surgically resected clear margins of oral squamous cell carcinoma

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Oral squamous cell carcinoma (OSCC) is one of the most well-known malignancies that affect the human population worldwide.The early diagnosis and early intervention of OSCC help improve the survival rate of the patients.The tumour free surgical margins are mk holy llama a positive prognostic factor for recurrence-free survival.The molecular markers can be used to detect the tumour free surgical margins.Aim: The aim of the study is to evaluate the expression of p53 & Cyclin D1 marker in resected surgical apparently clear margins and to correlate the p53 & Cyclin D1 expression with clinicopathological characteristics and patient outcome.

Methods: The study population included retrospective cases of OSCC with apparently clear margins (2017-18) n=10 and Clinicopathological variables relevant to survival analysis were recorded.Finally, two margins were selected from each case, a total of 20 margins were included in this study.Paraffin-embedded wax blocks retrieved and tissue sections were made.Expression of cyclin D1 and p 53 was assessed by the immunohistochemical staining procedure Results: Positive expressions Cyclin D1 in 40% of mild dysplasia margins and 60% in clearance adequate margins were present.p53 expression was seen in 16% of mild dysplasia margins and 84% in clearance adequate margins.

The expression of p53 and Cyclin D1 molecular markers are noted in the basal & duvaltc.com parabasal layer of epithelium.Conclusion: Molecular markers could play a more reliable method for the assessment of dysplasia at the margins.